Clinical Trials

Please Visit Canadian Centre for Clinical Trials for more information.

• Chronic Kidney Disease
• Ulcerative Colitis
• Gout
• Observational Gout
• COPD Studies
• Asthma
• Diabetes

 

 

Chronic Kidney Disease (located in North York)

• Inclusion Criteria:
  • Patients must be minimum 18 years of age
  • Patients must have a history of moderate to severe chronic kidney disease
• Exclusion Criteria:
  • Patients on dialysis

Ulcerative Colitis (UC) Study (located in North York)

• Inclusion Criteria:
  • Male or nonpregnant female subjects aged 18 to 75 years
  • Patient may have newly diagnosed or recurrent mild to moderate UC
  • Extent of colonic involvement confirmed within the past 36 months by colonoscopy
• Exclusion Criteria:
  • Subjects with short bowel syndrome
  • Subjects with prior bowel surgery
  • Subjects with severe/fulminant UC
  • Subjects with infectious diseases (HIV, HBV or HCV infections)
  • Subjects intorlerant or allergic to aspirin or salicylates
  • Subjects with malignancies
  • Subjects who participated in another clinical study in the last 30 days

Gout Study (located in Thornhill)

• Patients between the ages of 18-75 years old
• Trial length is approximately 13 weeks with an option to extend to 6 months
• Male subjects or female subjects with post-menopause or surgical sterility
• Patient has to be taking 300 mg of allopurinol for at least 3 months
• Cannot have any serious cardiovascular problems
• No kidney or liver problems
• Patients will be compensated $50.00 and more per clinical visit

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Observational Gout Study (located in Thornhill)

• Patients must be over 18 years
• Subjects must be diagnosed with gout for at least 2 years
• Must have had at least 3 flares in the past 12 months
• Only one clinic visit required

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COPD Studies (located in Mississauga)

• Mild COPD Study: current or former smokers with FEV 1 between 40 and 80% of predicted normal value and FEV1/FVC less than 70
• Severe COPD Study: current or former smokers with FEV 1 between 30 and 65% of predicted value and FEV1/FVC less than 70
• Inclusion Criteria:
  • Patients must be over 40 years of age
  • Patients must have spirometry test results of the above mentioned criteria
  • Patients must have history of smoking equal or more than a pack a day for the last 10 years
  • Patients must have no significant cadriovascular conditions and not on any beta blockers
  • No history of malignancy in the past 5 years
• Exclusion Criteria:
  • Patients with asthma history or who require regular oxygen therapy
  • Patients with a BMI greater than 40kg/m2
  • Patients with uncontrolled diabetes (Hba1c greater than 8)
  • Patients with lung cancer. Night shift workers
• Patients will be compensated for their time

Asthma Study (located in Mississauga)

• Patients must be 18 years or age or more
• Patients must have history of moderate to severe asthma
• Patients must not have smoked in the past year
• Patients must have a smoking history of less than a pack a day for 10 years
• Patients with no significant cardiovascular conditions and not on any beta blockers

Diabetes Study (located in Mississauga)

• Patients should be on Metformin only for at least 2 months
• Patients will be compensated for their time

Clinical Trial History

• Diabetic Peripheral Neuropathy Study
• Migraine Study
• Gout Study

Diabetic Peripheral Neuropathy Study (completed)

• Diabetic patients with peripheral diabetic neuropathy with typical pain, paraesthesia, allodynia etc.
• Inclusion Criteria:
  • Mean Daily Average DPN pain score of at least 4 on an 11-point scale in the baseline period
  • Experienced DPN pain on a daily basis for the last 3 months
  • Have symptoms of DPN for at least 6 months prior to the study entry (this should be confirmed by the history and findings on the neurological examination
  • Patient is willing to discontinue treatment for chronic pain and other prohibited medications
  • Have a stable diabetic treatment regimen for the last 3 months prior to screening
  • Documented daily average DPN assessments for at least 5 days in the baseline period (daily calls for the duration of the study)
• Exclusion Criteria:
  • There are 33 exclusions which are the standard ones for most of the studies, with some additions:
  • Currently taking Coumadin
  • History of chronic pain (e.g. joint osteoarthritis or lo back pain) that is more severe than DPN
• Patients compensated $50 for the short visits (5 days) or $100 for the long visits (4 days)

Migraine Study (completed)

• Duration of the study approximately 8 months (13 clinical visits included in this duration)
• Patients compensated $50 for each visit
• Inclusion:
  • at least three migraine headache attacks per month
  • at least four migraine headache days per month but less than 15 total headache days per month
  • A history of migraine headaches for at least one year
  • Age of onset of migraine headaches prior to 50 years
• Exclusion:
  • A history of opioid use for more than 10 days per month
  • A history of simple analgesic use for more than 15 days per month
  • A history of seizure disorder(s)
  • A history of cluster headaches or basilar, ophthalmoplegic, hemiplegic, or transformed migraine headaches

Gout Study (completed)

• Patients between the ages of 18-75 years old
• Trial length approximately 13 weeks with an option to extend to 6 months
• Male or female subjects with post-menopause or surgical sterility, who are all hyperuricemic
• Patients compensated $50.00 and more per clinical visit